REVIEW: PENGGUNAAN MATRIKS PADA SISTEM PELEPASAN EXTENDED RELEASE SEDIAAN TABLET METFORMIN HCL
نویسندگان
چکیده
Terapi farmakologi lini pertama pada pasien diabetes melitus terutama tipe II obesitas dan yang memiliki fungsi ginjal normal adalah metformin. Namun, metformin dengan sistem pelepasan segera ditemukan banyak kelemahan seperti menimbulkan efek samping rendahnya kepatuhan pasien. Untuk mengatasi hal tersebut, maka dikembangkan formulasi diperpanjang (extended release). Tujuan penulisan review artikel ini memberikan informasi gambaran mengenai matriks dapat digunakan untuk tablet metfomin HCl extended release khususnya controlled sustained release. Review menggunakan metode penelitian komparatif dari 21 jurnal bahasa inggris indonesia membahas sediaan (sustained release), rentang tahun 2012 hingga 2022. Dapat disimpulkan bahwa hasil mengindikasikan dibuat dalam bentuk guar gum polivinil pirolidon K30, poli magnesium akrilat, eudragit RS 30D, natrium alginate, kitosan.
منابع مشابه
Design and release characteristics of sustained release tablet containing metformin HCl
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ژورنال
عنوان ژورنال: Medical sains : jurnal ilmiah kefarmasian
سال: 2022
ISSN: ['2548-2114']
DOI: https://doi.org/10.37874/ms.v7i3.411